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Multicenter Study of Hydroxyurea (MSH) demonstrated that hydroxyurea administration to adults with severe SCD phenotypes resulted in a reduction in pain crisis, acute chest syndrome, hospitalizations and transfusion requirements.

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Hydroxyurea for the treatment of severe sickle cell anemia: A pediatric clinical trial.

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If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

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Although we believe hydroxyurea to be safe and effective, additional studies of the safety, clinical effectiveness, and cost-effectiveness are required.

Pharmacokinetics and pharmacodynamics of hydroxyurea treatment for children with SCD have documented interpatient variability, with coefficients of variation for most pharmacokinetic parameters exceeding 30%.

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Priapism, although uncommon in the general population, is one of the most serious complications associated with sickle cell disease.

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Droxia is an antineoplastic used by people suffering from sickle cell to reduce the number of painful episodes and blood transfusions.

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Controlled, clinical trials are required to assess the role of anti-VEGF agents in treatment of patients with PSR via the intravitreal route.

Sick animals are more inclined to keep up their water intake, but still need to be observed to ensure that they are doing this.

In people with SCD and AVN, what are the most effective management strategies to reduce pain and functional disability (e.

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It happens when a large number of sickle cells get trapped in the spleen and cause it to suddenly get large.

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In severe cases, systemic medications such as retinoids (acitretin), methotrexate, cyclosporine, 6-thioguanine, azathioprine, a biologic, or hydroxyurea may be necessary for adequate control.

Its disadvantages include cost, length of time required to do the test, and its limitation to measure iron content in the liver only and not in other organs.

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The most serious dangers are acute chest syndrome, long-term damage to major organs, stroke, and complications during pregnancy.

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Viral infections that affect the liver may be independent of or secondary to red cell transfusions.

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